KDM4A Antikörper (AA 75-155)

Produktnummer ABIN872374

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch KDM4A in ELISA, IHC (p), IHC (fro), IF (p) und IF (cc). Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für KDM4A Antikörper (AA 75-155) (ABIN872374)

Target: KDM4A (Lysine (K)-Specific Demethylase 4A (KDM4A))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDM4A Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Produktdetails anti-KDM4A Antikörper

Bindungsspezifität: AA 75-155

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Sheep,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human JMJD2A/KDM4A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu KDM4A

Target: KDM4A (Lysine (K)-Specific Demethylase 4A (KDM4A))

Andere Bezeichnung: JMJD2A

Hintergrund:

Synonyms: JMJ2A, JmjC domain containing histone demethylation protein 3A, JmjC domain-containing histone demethylation protein 3A, JMJD2, jumonji C domain containing histone demethylase 3A, Jumonji domain containing 2, Jumonji domain containing 2A, Jumonji domain containing protein 2A, Jumonji domain-containing protein 2A, KDM4A, KDM2A_HUMAN, KIAA0677, Lysine-specic demethylase 4A.

Background: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.

Pathways: Warburg Effekt